Medications and Genes Tested
The information from the GeneSight test can help your healthcare provider select the medication(s) and dose(s) that are best suited to your condition and genetic makeup. Medicines that align well with your genes may work better with fewer side effects.
The GeneSight Psychotropic test analyzes how your genes affect the way your body may respond to FDA-approved medications commonly prescribed to treat depression, anxiety, bipolar disorder, posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder, obsessive compulsive disorder, schizophrenia or other behavioral health conditions. The test provides information regarding 99% of antidepressant prescriptions for depression.1
Pharmacokinetic Genes Cytochrome P450 2D6 (CYP2D6), 2C19 (CYP2C19), 2C9 (CYP2C9), 3A4 (CYP3A4), 2B6 (CYP2B6), 1A2 (CYP1A2) and Serotonin Transporter and Receptor Pharmacodynamic Genes SLC6A4 and HTR2A.
The GeneSight Analgesic test analyzes how your genes affect the way your body may respond to FDA-approved opioids, NSAIDs, and muscle relaxants commonly prescribed to treat acute and chronic pain, opioid dependency, osteoarthritis (OA), rheumatoid arthritis (RA), and juvenile rheumatoid arthritis (JRA). The test provides information regarding 98% of prescriptions for low back pain.1
Pharmacokinetic Genes Cytochrome P450 2D6 (CYP2D6), 2C19 (CYP2C19), 2C9 (CYP2C9), 3A4 (CYP3A4), 2B6 (CYP2B6), 1A2 (CYP1A2) and Opioid Pharmacodynamic Gene OPRM1.
The GeneSight ADHD test analyzes how genes affect the way one’s body may respond to FDA-approved medicines commonly prescribed to treat ADHD or narcolepsy. The test provides information to healthcare providers on 100% of the FDA-approved medications for ADHD.1
Pharmacokinetic Gene Cytochrome P450 2D6 (CYP2D6) and Pharmacodynamic Genes COMT and ADRA2A.
The GeneSight MTHFR test analyzes one important gene to predict how your body converts folic acid into its active form. Folic acid must be in its active form for your body to use it. This information will help your healthcare provider decide if you would benefit from taking an additional folic acid supplement. Folate deficiency can result in abnormal homocysteine levels and may interfere with the creation of dopamine, norepinephrine, and serotonin.
1. IMS Health NDTI quarterly projected drug utilization data from 2011-2013