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GeneSight® Psychotropic Report Details

What does the GeneSight Psychotropic report show?
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The GeneSight report uses color-coding to show which medicines may be more likely to work for a patient and which may require dose adjustments, may be less likely to work, or may have an increased risk of side effects based on the patient's genetic makeup.
The GeneSight test analyzes how your patient's genes may affect their response to more than 60 FDA-approved medications used to treat depression, anxiety, and other behavioral health conditions. This precision medicine tool can help you develop an individualized treatment plan for your patients.
Learn more about the Gene-Drug Interaction Chart here.
Use As Directed
These medications are not associated with any known genetic issues that would be expected to change patient medication response.
Moderate Gene-Drug Interaction
These medications may require dose adjustments in order to have the desired effect or they may be less likely to work.
Significant Gene-Drug Interaction
These medications are likely to require dose adjustments in order to have the desired effect, may be less likely to work, or may cause side effects.
Clinical Considerations
These state rationale for a medication’s classification and offer treatment adjustments if a clinician desires to use this medication.
CLINICAL CONSIDERATIONS
1: Serum level may be too high, lower doses may be required.
2: Serum level may be too low, higher doses may be required.
3: Difficult to predict dose adjustments due to conflicting variations in metabolism.
4: Genotype may impact drug mechanism of action and result in reduced efficacy.
5: CYP2D6 genotype indicates that this patient may experience increased frequency of side effects but also greater symptom improvement in those who find the treatment tolerable.
6: Use of this drug may increase risk of side effects.
7: Serum level may be too low in smokers.
8: FDA label identifies a potential gene-drug interaction for this medication.
9: Per FDA label, this medication is contraindicated for this genotype.
10: While this medication does not have any clinically proven genetic markers that allow it to be categorized, it may be an effective choice based on other clinical factors.
Pharmacodynamic Genes
Pharmacodynamic genes provide information on how DNA may impact response to some medications.
Pharmacokinetic Genes
Pharmacokinetic genes provide information on the metabolism of medications.
Additional Genotypes
The COMT genotype is provided for informational purposes.
Gene-drug interactions are reported for every medication and gene to provide important details to the physician.
Gene-Drug Interaction Chart
This chart shows which PK pathways each drug uses and whether that pathway is compromised based on a person’s genetic makeup.
Combinatorial Approach
Our combinatorial pharmacogenomic algorithm weights multiple genetic pathways to determine the overall effect of a medication on a given patient.
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