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GeneSight® Tests: Psychotropic and MTHFR

How Does it Work?

The GeneSight Report

GeneSight at Home

Educational Resources

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The GeneSight Psychotropic Test

The GeneSight Psychotropic test analyzes how your genes may affect your outcomes with medications commonly prescribed to treat depression, anxiety, ADHD, and other mental health conditions. The GeneSight Psychotropic test provides your clinician with information about which medications may require dose adjustments, may be less likely to work for you or may have an increased risk of side effects based on your genetic makeup.

View Sample GeneSight Psychotropic Report >

The GeneSight MTHFR Test

The GeneSight MTHFR test shows whether a person has variation in MTHFR, an enzyme required to convert folic acid and dietary folate into its active form, L-methylfolate.

View Sample GeneSight MTHFR Report >

See The GeneSight Test Process

The GeneSight Test Process

To register to provide the GeneSight test, or if interested in taking the GeneSight test by referring or finding a registered provider, please start here.

Step 1

Your clinician collects a DNA sample in clinic by painlessly swabbing the inside of your cheek OR your clinician can order a patient collection kit to be sent to your home.

Step 2

The sample is sent to our lab for analysis.

Step 3

Test results are received and processed back typically within 2 business days.

Step 4

Results will be available from our portal and can be reviewed with the patient on their next visit. A clinician can contact our Medical Information team to review the patient’s results together.

To register to provide the GeneSight test, or if interested in taking the GeneSight test by referring or finding a registered provider, please start here.

Step 1

Your clinician collects a DNA sample in clinic by painlessly swabbing the inside of your cheek OR your clinician can order a patient collection kit to be sent to your home.

Step 2

The sample is sent to our lab for analysis.

Step 3

Test results are received and processed back typically within 2 business days.

Step 4

Results will be available from our portal and can be reviewed with the patient on their next visit. A clinician can contact our Medical Information team to review the patient’s results together.

A comprehensive report, personalized for you

The GeneSight Psychotropic report may help you avoid multiple medication trials by providing information about which medications may require dose adjustments, be less likely to work, or have an increased risk of side effects based on your genetic information.

The report also includes information on how a patient’s smoking status may affect their body’s metabolism of certain medications.

The report classifies over 60 mental health medications into four categories:

Use as Directed
Moderate Gene-Drug Interaction
Significant Gene-Drug Interaction
No Proven Genetic Markers

Medications on the GeneSight Psychotropic Report

There are over 60 mental health medications included on the GeneSight Psychotropic test. We continuously evaluate the scientific literature and are committed to providing clinicians with genetic insights to help inform treatment decisions.

Medication List (scroll horizontally to see the full list, click on each to read description)

Abilify®
(aripiprazole)

Ambien®
(zolpidem)

Anafranil®
(clomipramine)

Ativan®
(lorazepam)

Belsomra®
(suvorexant)

Buspar®
(buspirone)

Caplyta®
(lumateperone)

Celexa®
(citalopram)

Concerta®
(methyl-
phenidate)

Clozaril®
(clozapine)

Cymbalta®
(duloxetine)

Dayvigo®
(lemborexant)

Depakote®
(valproic acid/
divalproex)

Desyrel®
(trazodone)

Effexor XR®
(venlafaxine)

Elavil®
(amitriptyline)

Emsam®
(selegiline)

Fanapt®
(iloperidone)

Fetzima®
(levomilnacipran)

Focalin®
(dexmethyl-
phenidate)

Geodon®
(ziprasidone)

Haldol®
(haloperidol)

Inderal®
(propranolol)

Intuniv®
(guanfacine)

Invega®
(paliperidone)

Klonopin®
(clonazepam)

Lamictal®
(lamotrigine)

Latuda®
(lurasidone)

Lexapro®
(escitalopram)

Librium®
(chlordiazepoxide)

Lunesta®
(eszopiclone)

Luvox®
(fluvoxamine)

Mellaril®
(thioridazine)

Navane®
(thiothixene)

Norpramin®
(desipramine)

Pamelor®
(nortriptyline)

Paxil®
(paroxetine)

Pristiq®
(desvenlafaxine)

Prolixin®
(fluphenazine)

Prozac®
(fluoxetine)

Qelbree®
(vioxazine)

Remeron®
(mirtazapine)

Restoril®
(temazepam)

Rexulti®
(brexpiprazole)

Risperdal®
(risperidone)

Ritalin®
(methyl-
phenidate)

Saphris®
(asenapine)

Serax®
(oxazepam)

Seroquel®
(quetiapine)

Sinequan®
(doxepin)

Strattera®
(atomoxetine)

Tegretol®
(carbamazepine)

Thorazine®
(chlorpramazine)

Tofranil®
(imipramine)

Tranxene®
(clorazepate)

Trilafon®
(perphenazine)

Trileptal®
(oxcarbazepine)

Trintellix®
(vortioxetine)

Valium®
(diazepam)

Viibryd®
(vilazodone)

Vraylar®
(cariprazine)

Wellbutrin®
(buproprion)

Xanax®
(alprazolam)

Zoloft®
(sertraline)

Genes on the GeneSight Psychotropic Report

PK
Pharmacokinetic Genes
PD
Pharmacodynamic Genes
+
Additional Genotypes

How We Offer the GeneSight Test

In Clinic GeneSight test

The GeneSight test is ordered and administered by your healthcare provider. The test is a simple cheek swab taken in your healthcare provider’s office.

GeneSight at Home

The GeneSight test is ordered by your healthcare provider and sent directly to you, so you may take it in the convenience of your home. The test is a simple cheek swab, taken in your home, and returned to our lab via FedEx for processing.

Educational Resources for You

Understanding the GeneSight test algorithm

Understanding the GeneSight test algorithm The GeneSight test uses a unique combinatorial algorithm, which evaluates how variations in multiple genes may influence an individual’s outcomes with certain medications. The algorithm…
Read More

Resources

Explore our collection of GeneSight® resources and educational materials to help you better understand what the GeneSight test can do for you.

Read More

Learn More about GeneSight® Testing

If you’re interested to learn more about the GeneSight test, please fill out the form below. The GeneSight test must be ordered by a registered clinician. If you are a patient/caregiver who would like your current clinician to be registered to administer the GeneSight test, please include their name and contact information.

If you are a current registered provider or tested patient, please contact us.

Please fill out the form below to take the next step.

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If you do not have a clinician, we have a directory of healthcare providers who are registered to order the GeneSight test. When you complete this form, we will link you to this directory, so you will have the option to view registered GeneSight providers in your area.







If you do not have a clinician, we have a directory of healthcare providers who are registered to order the GeneSight test. When you complete this form, we will link you to this directory, so you will have the option to view registered GeneSight providers in your area.

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