HomeProvider StoriesHelps reduce the number of variables Helps reduce the number of variables November 11, 2020 Josh Sizemore, RN, MN, PMHNP-BCOregon I’m known in Oregon for treating complex patient cases. Many of the patients I see aren’t presenting with just one condition – they have multiple illnesses, developmental disabilities, and other physical or mental conditions. For example, I may see a patient who is between 15 and 25 years of age and has a psychiatric break. But this may be completely atypical, and so I need to figure out what is really going on. There are always more people to treat than you could possibly have time for. Because I’m seeing patients with complex pictures, it is important for me to stabilize them as quickly as possible. I do a thorough assessment and use everything at my disposal to help my patients. One of the tools I use is the GeneSight test. Reducing the Number of Variables When you are looking at a complex patient picture, you want to limit the number of variables. Especially in the case of severe mental illness – you are trying to narrow down and pinpoint what’s really going on and what you need to do. You just don’t have a lot of time for errors. Families will stick with you for a while, but results matter. At the same time, conditions can be complex. For example, depression can be caused by 1,000 different things. My patient treatment philosophy is that we need to get to the root cause of depression, not just treat the diagnosis. I try to figure out the likeliest reason for depression: is it biological, genetic, conditional, or something else? The GeneSight test helps me reduce some of the variables in treatment decisions. After I order the GeneSight test, I will meet with the patient and their caregiver if appropriate to give them the results. I will NOT go through the GeneSight test results over the phone. It is much too complex. I take time to walk through the results report and share how to interpret the report. Further, I explain what’s important in the context of the entire medical assessment. When someone leaves my office, I share with them what they should hope to see, a timeline for medication response, and what they won’t want to see based on the medication. Part of My Tools to Help Patients I would say the GeneSight test helps me with my most vulnerable patients. For example, I had one highly ill patient who was on 13 different psychiatric meds when I first started seeing them, and still unstable even on that many medications. I was told by the locked, long-term facility where the patient was residing that the patient wouldn’t likely ever be stable enough to leave the facility. I ordered a GeneSight test, and using the genetic testing results, I created a detailed medication plan reducing the number of medications that showed a genetic conflict. My new medication regime for the patient reduced the number of medications down to seven. The new medication regime started to work for the patient. They began to stabilize and, most importantly, the patient was discharged from long-term facility within a year. If I were to talk to another clinician about the GeneSight test, I would tell them that if they want to increase their overall effectiveness and help patients get better, the GeneSight test may help them, as long as they can fully understand and interpret the report. Patient Rooting for Mental Health Heroes at the 2026 Winter Olympics The Winter Olympics has brought us unforgettable moments—Miracle on Ice, Torvill and Dean’s Bolero, the Jamaican bobsled team. They also showed heartbreak: cras... Read more Healthcare Provider PRIME Care Time-to-Event Analysis In 2022, the United States Department of Veterans Affairs (VA) undertook the Precision Medicine in Mental Health Care, or PRIME Care study, the largest phar... 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Read more Patient Empowering Senior Patient Care with Pharmacogenomics: Insights from the GeneSight Engage Webinar The most recent GeneSight Engage webinar explored how pharmacogenomic testing, particularly the GeneSight® test, is transforming the landscape of mental health ... Read more Patient BIPOC (formerly Minority) Mental Health Month: Breaking Stigma, Building Trust Despite many efforts to stem it, stigma around mental health still exists, particularly in BIPOC (Black, Indigenous, and People of Color) communities. July mark... Read more Patient Long-Term Effects of Antidepressants: What Research Shows Anyone who’s ever taken antidepressants for an extended period of time has probably wondered whether they’ll experience long-term effects: After years ... Read more Patient Have a Mindful Summer: Take a Breather with These Simple Exercises Summer is a great time to kick back and relax—if you can find the time. Managing the hustle and bustle of kids off school, planning for fun summer activities an... Read more Learn more Learn more about GeneSight How to talk to your provider View our clinical studies
Patient Rooting for Mental Health Heroes at the 2026 Winter Olympics The Winter Olympics has brought us unforgettable moments—Miracle on Ice, Torvill and Dean’s Bolero, the Jamaican bobsled team. They also showed heartbreak: cras... Read more
Healthcare Provider PRIME Care Time-to-Event Analysis In 2022, the United States Department of Veterans Affairs (VA) undertook the Precision Medicine in Mental Health Care, or PRIME Care study, the largest phar... Read more
Patient Healthcare Provider The GeneSight® Test: Announces New Updates As part of our ongoing commitment to ensuring that our tests evolve with the latest scientific research and clinical needs, we’ve updated the GeneSight Test. Th... Read more
Patient Is “Anxiety” on Your Playlist? “Anxiety, keep on tryin' me I feel it quietly, tryna silence me, yeah Anxiety, shake it off of me Somebody's watchin' me, it's my anxiety, yeah (Brrah) …And... Read more
Patient Break the resolution cycle: How simple solutions can transform 2026 Like every year, many of us make New Year’s resolutions and try to stick to them, but broad, all-or-nothing changes often set us up for failure and can make... Read more
Patient Antidepressant Fatigue in Seniors: A Caregiver’s Guide to Reducing Daytime Sleepiness Without Losing Symptom Control You’re spending time with the older adult in your care who also happens to have clinical depression. You’re keeping tabs on how well they’re doing and wheth... Read more
Patient Empowering Senior Patient Care with Pharmacogenomics: Insights from the GeneSight Engage Webinar The most recent GeneSight Engage webinar explored how pharmacogenomic testing, particularly the GeneSight® test, is transforming the landscape of mental health ... Read more
Patient BIPOC (formerly Minority) Mental Health Month: Breaking Stigma, Building Trust Despite many efforts to stem it, stigma around mental health still exists, particularly in BIPOC (Black, Indigenous, and People of Color) communities. July mark... Read more
Patient Long-Term Effects of Antidepressants: What Research Shows Anyone who’s ever taken antidepressants for an extended period of time has probably wondered whether they’ll experience long-term effects: After years ... Read more
Patient Have a Mindful Summer: Take a Breather with These Simple Exercises Summer is a great time to kick back and relax—if you can find the time. Managing the hustle and bustle of kids off school, planning for fun summer activities an... Read more