HomeBlogPatientWinter is Coming: Vitamin D & Depression Winter is Coming: Vitamin D & Depression October 29, 2018Patient Winter is lurking; it’s right around the corner. With colder temperatures, some people look forward to “sweater weather,” cozying up around a fire and engaging in winter sports. What people don’t look forward to are the gray days and lack of sunlight that winter can bring. Sunlight delivers vitamin D, and a lack of it has been associated with depression. Vitamin D is activated in our bodies when UV rays from sunlight strike the skin. According to the Healthline newsletter, “unlike other vitamins, vitamin D functions like a hormone, and every single cell in your body has a receptor for it.” A lack of vitamin D is more common than you might think. The journal, Age and Aging, reported that as many as 1 billion people may suffer from vitamin D deficiency. Many may not even know they have a deficiency because symptoms are often subtle. Signs of Vitamin D Deficiencies Healthline indicates that “you may not recognize [vitamin D deficiency symptoms] easily, even if they’re having a significant negative effect on your quality of life.” Some of the more common impacts of the deficiency can include: Getting sick more often, as vitamin D helps your immune system fight illness Exhaustion, including chronic fatigue and tiredness Bone pain or bone loss, as vitamin D helps your body absorb calcium Additionally, vitamin D deficiency may lead to depression – though the jury is still out. Research has shown that vitamin D receptors in part of the brain have been identified as contributors to the regulation of moods. However, research has been conflicted on whether a vitamin D deficiency causes depression… or if depression causes a vitamin D deficiency. Is There a Connection Between Vitamin D and Depression? Possibly. According to Psychology Today, research has suggested that people with depression may produce less vitamin D, which is believed to play a role in serotonin activity. Further, it writes that vitamin D insufficiency may be associated with clinically significant depression symptoms. Recent research from Oregon State University found a correlation between depression and vitamin D in young, otherwise healthy, women. The study included 185 female college students, who had their vitamin D levels measured with blood tests at different times during the school year and completed a depression symptom survey every week for five weeks. The study found that more than 60 percent of participants had vitamin D levels below what is considered enough (most experts agree on a vitamin D blood level of at least 20 nanograms per milliliter). Further, the study found that vitamin D levels varied depending on the time of year – declining in the fall, lowest in winter, and higher in the spring. Perhaps most interestingly, the lower the women’s levels of vitamin D, the more likely they were to have clinically significant symptoms of depression. The Right Amount of Vitamin D A blood test can be used to determine whether your own vitamin D levels are within normal ranges. The Vitamin D Council recommends that healthy adults take 2,000 IU of vitamin D daily, even more if they get little or no sun exposure. The Institute of Medicine’s Food and Nutrition Board say 600 IU/day is enough for adults and the Endocrine Society says 2,000 IU/day is enough for most adults. Segments of the population who are more likely to be vitamin D deficient include people with darker skin, people who spend a lot of time indoors during the day, and people that live in the northern part of the United States or in Canada. Using Vitamin D to Fight Depression Regardless of why you might be experiencing depression, if you’ve been battling it over the course of many months or years, finding the right medication for you could help. Be sure to talk to your healthcare provider about how to manage your depression, including medication, alternative treatments, exercise, or nutrition including, potentially, vitamin D supplements. To read more about this topic, please read our blog post at https://genesight.com/blog/patient/studies-remain-inconclusive-on-vitamin-d-and-depression/. Our articles are for informational purposes only and are reviewed by our Medical Information team, which includes PharmDs, MDs, and PhDs. Do not make any changes to your current medications or dosing without consulting your healthcare provider. The GeneSight test must be ordered by and used only in consultation with a healthcare provider who can prescribe medications. As with all genetic tests, the GeneSight test results have limitations and do not constitute medical advice. The test results are designed to be just one part of a larger, complete patient assessment, which would include proper diagnosis and consideration of your medical history, other medications you may be taking, your family history, and other factors. If you are a healthcare provider and interested in learning more about the GeneSight test, please contact us at 855.891.9415. If you are a patient, please talk with your doctor to see if the GeneSight test may be helpful. Patient Rooting for Mental Health Heroes at the 2026 Winter Olympics The Winter Olympics has brought us unforgettable moments—Miracle on Ice, Torvill and Dean’s Bolero, the Jamaican bobsled team. They also showed heartbreak: cras... Read more Healthcare Provider PRIME Care Time-to-Event Analysis In 2022, the United States Department of Veterans Affairs (VA) undertook the Precision Medicine in Mental Health Care, or PRIME Care study, the largest phar... Read more Patient Healthcare Provider The GeneSight® Test: Announces New Updates As part of our ongoing commitment to ensuring that our tests evolve with the latest scientific research and clinical needs, we’ve updated the GeneSight Test. Th... Read more Patient Is “Anxiety” on Your Playlist? “Anxiety, keep on tryin' me I feel it quietly, tryna silence me, yeah Anxiety, shake it off of me Somebody's watchin' me, it's my anxiety, yeah (Brrah) …And... Read more Patient Break the resolution cycle: How simple solutions can transform 2026 Like every year, many of us make New Year’s resolutions and try to stick to them, but broad, all-or-nothing changes often set us up for failure and can make... Read more Patient Antidepressant Fatigue in Seniors: A Caregiver’s Guide to Reducing Daytime Sleepiness Without Losing Symptom Control You’re spending time with the older adult in your care who also happens to have clinical depression. You’re keeping tabs on how well they’re doing and wheth... Read more Patient Empowering Senior Patient Care with Pharmacogenomics: Insights from the GeneSight Engage Webinar The most recent GeneSight Engage webinar explored how pharmacogenomic testing, particularly the GeneSight® test, is transforming the landscape of mental health ... Read more Patient BIPOC (formerly Minority) Mental Health Month: Breaking Stigma, Building Trust Despite many efforts to stem it, stigma around mental health still exists, particularly in BIPOC (Black, Indigenous, and People of Color) communities. July mark... Read more Patient Long-Term Effects of Antidepressants: What Research Shows Anyone who’s ever taken antidepressants for an extended period of time has probably wondered whether they’ll experience long-term effects: After years ... Read more Patient Have a Mindful Summer: Take a Breather with These Simple Exercises Summer is a great time to kick back and relax—if you can find the time. Managing the hustle and bustle of kids off school, planning for fun summer activities an... Read more Learn more Learn more about GeneSight How to talk to your provider View our clinical studies
Patient Rooting for Mental Health Heroes at the 2026 Winter Olympics The Winter Olympics has brought us unforgettable moments—Miracle on Ice, Torvill and Dean’s Bolero, the Jamaican bobsled team. They also showed heartbreak: cras... Read more
Healthcare Provider PRIME Care Time-to-Event Analysis In 2022, the United States Department of Veterans Affairs (VA) undertook the Precision Medicine in Mental Health Care, or PRIME Care study, the largest phar... Read more
Patient Healthcare Provider The GeneSight® Test: Announces New Updates As part of our ongoing commitment to ensuring that our tests evolve with the latest scientific research and clinical needs, we’ve updated the GeneSight Test. Th... Read more
Patient Is “Anxiety” on Your Playlist? “Anxiety, keep on tryin' me I feel it quietly, tryna silence me, yeah Anxiety, shake it off of me Somebody's watchin' me, it's my anxiety, yeah (Brrah) …And... Read more
Patient Break the resolution cycle: How simple solutions can transform 2026 Like every year, many of us make New Year’s resolutions and try to stick to them, but broad, all-or-nothing changes often set us up for failure and can make... Read more
Patient Antidepressant Fatigue in Seniors: A Caregiver’s Guide to Reducing Daytime Sleepiness Without Losing Symptom Control You’re spending time with the older adult in your care who also happens to have clinical depression. You’re keeping tabs on how well they’re doing and wheth... Read more
Patient Empowering Senior Patient Care with Pharmacogenomics: Insights from the GeneSight Engage Webinar The most recent GeneSight Engage webinar explored how pharmacogenomic testing, particularly the GeneSight® test, is transforming the landscape of mental health ... Read more
Patient BIPOC (formerly Minority) Mental Health Month: Breaking Stigma, Building Trust Despite many efforts to stem it, stigma around mental health still exists, particularly in BIPOC (Black, Indigenous, and People of Color) communities. July mark... Read more
Patient Long-Term Effects of Antidepressants: What Research Shows Anyone who’s ever taken antidepressants for an extended period of time has probably wondered whether they’ll experience long-term effects: After years ... Read more
Patient Have a Mindful Summer: Take a Breather with These Simple Exercises Summer is a great time to kick back and relax—if you can find the time. Managing the hustle and bustle of kids off school, planning for fun summer activities an... Read more