HomeBlogPatientChronic Illnesses & Depression: Breaking the Cycle Chronic Illnesses & Depression: Breaking the Cycle November 6, 2017Patient It’s a vicious cycle: depression increases the risk for chronic illness, and chronic illnesses may bring on episodes of depression. According to WebMD, up to one third of people with chronic illnesses also suffer from depression. Cardiovascular disease, stroke, cancer, diabetes, and other chronic conditions are strongly associated with depression. Depression Can Worsen Chronic Diseases According to a paper by Gregory Simon of the Center for Health Studies published in the Western Journal of Medicine, depression greatly increases the degree of illness in patients with chronic conditions. Patients with depression had almost twice as many days of restricted activity or missed work as who were not depressed. Depression is linked to a 50 percent to 100 percent increase in health services use and costs. Some behaviors linked to depression may make chronic illnesses worse, including: Not following treatment, including not taking prescribed medications Being more likely to smoke and drink Lack of exercise Poor eating habits Depression can cause physical fatigue, insomnia, anxiety and anorexia or binge eating. As your body is robbed of quality sleep, good nutrition, and restful periods of “me time,” it begins a downward spiral that puts you at higher risk for disease. According to a review of 31 studies in Dialogues in Clinical Neuroscience, patients with depression and chronic illnesses experienced a much higher number of medical symptoms, particularly pain and fatigue. Dr. Nelson Rodriguez, a staff psychiatrist at Cincinnati’s Lindner Center of HOPE, often sees comorbidity in his patients. “I’ve tried to understand the correlation between physical illnesses and mental illnesses,” says Dr. Rodriguez. “One of our roles as psychiatrists is to help educate our patients about the interactions between illnesses. “I see a number of first-time patients who are overweight, may complain of being tired during the day, or have trouble sleeping,” he explains “If they have trouble sleeping, I may refer them to a specialist for a sleep study to find out if they have sleep apnea. Once that is treated, they may experience relief from their symptoms of depression.” How Chronic Illness Impacts Depression The National Alliance on Mental Illness (NAMI) writes that dealing with a chronic illness can lead to “uncertainty, grief, sadness, anger or fear.” But if these feelings continue beyond a few days and affect normal daily functions, it may be a sign of depression. A NAMI fact sheet suggests that diet, exercise and good habits – along with medication and/or talk therapy – can help ease symptoms of depression and chronic illness. NAMI advises patients to try to remain involved in activities or learn new skills, maintain a daily routine, keep an active support network and practice proper self-care. The Cleveland Clinic advises patients to seek treatment for depression, stating, “Those with chronic medical conditions who get treatment for co-existing depression often experience an improvement in their overall medical condition, achieve a better quality of life, and find it easier to follow through with their treatment plan.” Most treatment studies have found that talk therapy and antidepressant medications are effective in treating depression in patients with depression and comorbid illnesses. Even if depression and chronic illness go hand in hand, it’s not an unbreakable bond. Speaking up, asking for help, and working with a health care team to establish the proper treatment can increase patients’ motivation for self-care and reduce symptoms. Our articles are for informational purposes only and are reviewed by our Medical Information team, which includes PharmDs, MDs, and PhDs. Do not make any changes to your current medications or dosing without consulting your healthcare provider. The GeneSight test must be ordered by and used only in consultation with a healthcare provider who can prescribe medications. As with all genetic tests, the GeneSight test results have limitations and do not constitute medical advice. The test results are designed to be just one part of a larger, complete patient assessment, which would include proper diagnosis and consideration of your medical history, other medications you may be taking, your family history, and other factors. If you are a healthcare provider and interested in learning more about the GeneSight test, please contact us at 855.891.9415. If you are a patient, please talk with your doctor to see if the GeneSight test may be helpful. Patient Rooting for Mental Health Heroes at the 2026 Winter Olympics The Winter Olympics has brought us unforgettable moments—Miracle on Ice, Torvill and Dean’s Bolero, the Jamaican bobsled team. They also showed heartbreak: cras... Read more Healthcare Provider PRIME Care Time-to-Event Analysis In 2022, the United States Department of Veterans Affairs (VA) undertook the Precision Medicine in Mental Health Care, or PRIME Care study, the largest phar... Read more Patient Healthcare Provider The GeneSight® Test: Announces New Updates As part of our ongoing commitment to ensuring that our tests evolve with the latest scientific research and clinical needs, we’ve updated the GeneSight Test. Th... 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Patient Rooting for Mental Health Heroes at the 2026 Winter Olympics The Winter Olympics has brought us unforgettable moments—Miracle on Ice, Torvill and Dean’s Bolero, the Jamaican bobsled team. They also showed heartbreak: cras... Read more
Healthcare Provider PRIME Care Time-to-Event Analysis In 2022, the United States Department of Veterans Affairs (VA) undertook the Precision Medicine in Mental Health Care, or PRIME Care study, the largest phar... Read more
Patient Healthcare Provider The GeneSight® Test: Announces New Updates As part of our ongoing commitment to ensuring that our tests evolve with the latest scientific research and clinical needs, we’ve updated the GeneSight Test. Th... Read more
Patient Is “Anxiety” on Your Playlist? “Anxiety, keep on tryin' me I feel it quietly, tryna silence me, yeah Anxiety, shake it off of me Somebody's watchin' me, it's my anxiety, yeah (Brrah) …And... Read more
Patient Break the resolution cycle: How simple solutions can transform 2026 Like every year, many of us make New Year’s resolutions and try to stick to them, but broad, all-or-nothing changes often set us up for failure and can make... Read more
Patient Antidepressant Fatigue in Seniors: A Caregiver’s Guide to Reducing Daytime Sleepiness Without Losing Symptom Control You’re spending time with the older adult in your care who also happens to have clinical depression. You’re keeping tabs on how well they’re doing and wheth... Read more
Patient Empowering Senior Patient Care with Pharmacogenomics: Insights from the GeneSight Engage Webinar The most recent GeneSight Engage webinar explored how pharmacogenomic testing, particularly the GeneSight® test, is transforming the landscape of mental health ... Read more
Patient BIPOC (formerly Minority) Mental Health Month: Breaking Stigma, Building Trust Despite many efforts to stem it, stigma around mental health still exists, particularly in BIPOC (Black, Indigenous, and People of Color) communities. July mark... Read more
Patient Long-Term Effects of Antidepressants: What Research Shows Anyone who’s ever taken antidepressants for an extended period of time has probably wondered whether they’ll experience long-term effects: After years ... Read more
Patient Have a Mindful Summer: Take a Breather with These Simple Exercises Summer is a great time to kick back and relax—if you can find the time. Managing the hustle and bustle of kids off school, planning for fun summer activities an... Read more