Clinical White Papers How Do I Use the Gene-Drug Interaction Chart? What is the gene-drug interaction chart? Healthcare providers and patients often inquire about how they can determine which genes may affect outcomes with ea... Read more
Clinical White Papers Get to know a gene: ANK3 Summary: ANK3 has not been shown to inform on patient medication response and therefore is not a pharmacogenomic marker. As a disease marker, it lacks clinical ... Read more
Clinical White Papers Get to know a gene: COMT Summary: The Val158Met polymorphism (rs4680) in the COMT gene can affect baseline levels of synaptic catecholamines. Several studies have assessed the impact of... Read more
Clinical White Papers Get to know a gene: ADRA2A Summary: The ADRA2A -1291 G>C polymorphism has been studied extensively with methylphenidate treatment outcomes in ADHD. While certain studies have produced ... Read more
Clinical White Papers Get to know a gene: UGT2B15 What is UGT2B15? The UGT2B15 gene encodes an enzyme responsible for glucuronidation, a phase II metabolic reaction that transforms small lipophilic molecules i... Read more
Clinical White Papers Get to know a gene: UGT1A4 What is UGT1A4? The UGT1A4 gene encodes an enzyme of the glucuronidation pathway, a phase II metabolism process that transforms small lipophilic molecules into... Read more
Clinical White Papers Get to know a gene: HTR2A What is HTR2A? The 5-HT2A receptor, encoded by the HTR2A gene, is responsible for post-synaptic serotonin signaling and is a target for many antipsychotics and... Read more
Clinical White Papers What do I do with an all green report? A medication falls in the green category when there is no variation found in the patient’s genes that is expected to impact their outcomes with that medication.... Read more
Clinical White Papers How do I choose patients for GeneSight® testing? The choice for psychiatric pharmacogenomic testing is entirely at the discretion of the healthcare provider. While pharmacogenomic testing has the potential to ... Read more