HomeBlogPatientThe Link Between Chronic Inflammation and Mental Health The Link Between Chronic Inflammation and Mental Health September 6, 2016Patient Chronic inflammation is a symptom you’ll see in a variety of different diseases, including asthma, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease and tuberculosis—and that’s just to name a few. But did you know that inflammation may also play an important role in the development of depression? Simply defined, inflammation is an immune process. And it’s a healthy one—to an extent. The immune system helps to protect the body from disease and injury by rolling out inflammatory processes. Those processes release protective molecules to fight off any invaders, clear out damaged cells and help the body heal. But sometimes this process is hijacked, becoming pathological in its own right. And, ultimately, chronic inflammation can result in a host of diseases. “More and more, we are finding that chronic inflammation can pair up with a certain genetic susceptibilities and it results in symptoms that we know as diseases. Depression is no different,” says Madeleine Castellanos, a functional medicine psychiatrist based in New York City. “When you have different imbalances in your body and in your life, in terms of vitamin and mineral deficiencies, gut bacteria and stress, that can result in too much inflammation and that can lead to depressive symptoms.” Doctors have long seen a correlation between infection and depression. Individuals with infections often look a bit like depressed patients with symptoms of sadness, irritability, and lack of joy. And recent studies have found that individuals who have high inflammation markers like c-reactive protein (CRP), a protein released in the liver during the inflammatory process, show lessened connectivity between brain regions that help facilitate motivation and overall enjoyment of life. Simply stated, important parts of the brain can no longer communicate effectively, which leads to a symptom called anhedonia, or the inability to feel pleasure or joy. Castellanos says this makes sense. “People want to think that disease is the result of some linear thing,” she explains. “But the body is a lot more like a web with a lot of different processes interacting all the time. When you tug on part of that web, and injure it, like you see with increased inflammation, everything else is going to change and move. And that can result in changes to sleep, hormones, and, yes, even mood.” Castellanos says patients who are feeling depressed should speak with their care providers about inflammation and its role in depression. Especially since there are plenty of simple lifestyle changes that people can make that can help reduce inflammation—and, in turn, depressive symptoms—and assist any other treatment that may be prescribed. “Things like maximizing micronutrients, reducing sugar, perhaps going on a ketogenic diet, making sure you’re getting enough zinc, exercising, good sleep,” she says. “These are things you can do to reduce overall inflammation in the body, reduce your symptoms, and, over time, help yourself to feel better.” The information on this website is provided as a general information resource only, and is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. Always seek the advice of your physician or qualified healthcare provider with any questions you may have regarding a medical condition. The information on this website is provided “as is”. Assurex Health makes no representations or warranties, express or implied, regarding the information on this website. Our articles are for informational purposes only and are reviewed by our Medical Information team, which includes PharmDs, MDs, and PhDs. Do not make any changes to your current medications or dosing without consulting your healthcare provider. The GeneSight test must be ordered by and used only in consultation with a healthcare provider who can prescribe medications. As with all genetic tests, the GeneSight test results have limitations and do not constitute medical advice. The test results are designed to be just one part of a larger, complete patient assessment, which would include proper diagnosis and consideration of your medical history, other medications you may be taking, your family history, and other factors. If you are a healthcare provider and interested in learning more about the GeneSight test, please contact us at 855.891.9415. If you are a patient, please talk with your doctor to see if the GeneSight test may be helpful. Patient Which Mental Health Provider Should I Consider? A Symptom-Based Guide The support of a good healthcare provider can make all the difference when you’re struggling with your mental health. But how do you connect to one in a sea of ... Read more Patient One explanation for why we experience Side Effects? Understanding Your Genetic Response to Antidepressants Antidepressants often play an essential role in helping patients with their mental health conditions. But as many patients can attest, it’s frustrating when... 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Patient Which Mental Health Provider Should I Consider? A Symptom-Based Guide The support of a good healthcare provider can make all the difference when you’re struggling with your mental health. But how do you connect to one in a sea of ... Read more
Patient One explanation for why we experience Side Effects? Understanding Your Genetic Response to Antidepressants Antidepressants often play an essential role in helping patients with their mental health conditions. But as many patients can attest, it’s frustrating when... Read more
Patient Barriers at Every Turn: How Systemic and Social Factors Block Men from Mental Health Care Taking the important step of seeking care for mental health isn’t always an easy decision. Uncertainty about the need for care, social stigmas associated wi... Read more
Healthcare Provider Overcoming Side Effect Concerns: Leveraging Pharmacogenomic Insights to Inform Depression and Anxiety Medication Selection Whitnee Brown, a lifelong resident now practicing in Birmingham, Alabama has nearly an entire alphabet following her name, abbreviations for degrees and certifi... Read more
Patient Concerns about Mental Health Medication Side Effects Remain a Barrier to Getting Help for Those Diagnosed with Depression and Anxiety Lisa Roberts has raised a family, reached an impressively high level in her career, and was an anchor for her mother and other family members. When, within ... Read more
Patient Common Antidepressant Side Effects Taking an antidepressant can be an effective way to help treat a mental health condition like depression or anxiety. However, these medications can also cre... Read more
Patient MTHFR Mutations: Clinical Implications and Management Strategies MTHFR mutations—changes in the methylenetetrahydrofolate reductase (MTHFR) gene—have gained increased attention in the medical community due to their potent... Read more
Patient Can an App Help Me Manage My Anxiety? Health and wellness smartphone apps have become so common that if you can name a health goal, desire or condition, you can probably find an app for it. N... Read more
Patient Black Trailblazers of Psychiatry and Mental Health: A Legacy of Healing and Advocacy As we celebrate Black History Month, we want to recognize a few individuals who have made extraordinary contributions to the field of psychiatry and mental heal... Read more
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