New VA study finds access to the GeneSight® test impacted treatment decisions and improved depression remission rates

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Study design

The PRIME Care study is the largest pharmacogenomic (PGx) randomized controlled trial (RCT) ever conducted in mental health.

The study investigated whether access to genetic testing results impacted treatment decisions and improved patient outcomes for those with MDD (Major Depressive Disorder).

The study was conducted across 22 VA Clinics with 676 clinicians.

1,944 veteran patients with MDD received the GeneSight Psychotropic test and were randomized to receive results immediately (GeneSight test arm) or after 24 weeks (treatment as usual arm).

The study was funded by the U.S. Department of Veteran Affairs and Myriad Genetics provided the GeneSight tests.

Learn more about RCTs

Study results

Patients more likely to achieve remission in GeneSight arm

Remission represents a reduction in symptoms and return to normal or near-normal function, which is considered the optimal treatment goal for both providers and patients.

Learn more about remission

Patients less likely to be prescribed medications with predicted gene-drug interactions in GeneSight arm

Gene-drug interactions are important because they can inform clinicians about a patient’s ability to metabolize or respond to a certain medication. This information can help clinicians understand how patients’ genes may affect outcomes with medications commonly prescribed to treat depression, anxiety, ADHD and other psychiatric conditions.

What is the GeneSight Psychotropic test?

The GeneSight Psychotropic test is a genetic test that shows your healthcare provider how your genes may affect medication outcomes.

The GeneSight test may reveal which medications to treat depression, anxiety, ADHD, and other mental health conditions that:

  • Require dose adjustments
  • Be less likely to work
  • Have an increased risk of side effects based on your DNA
How it works

Is the GeneSight test right for you?

Has a mental health medication failed you in the past?

Is your current mental health medication not working?

Does your mental health medication cause unwanted side effects?

We know the process of finding medication that works can be frustrating, time-consuming and debilitating.

Fewer than 50% of individuals with depression respond to their first medication.1

1. Rush AJ, et al. Am J Psychiatry, 2006.

Cost shouldn’t be a barrier to your mental wellness

Our goal is to make the GeneSight test affordable and accessible to patients.

Many insurance plans, including Medicare, often cover the entire or a significant portion of the test.

We offer a financial assistance plan for eligible patients to help with the cost of the GeneSight test.

If your cost is $100 or more, we offer an interest-free payment plan to spread out the cost for up to 12 months.

98%of patients pay $330 or less for their GeneSight test*

$0is the typical out-of-pocket cost for patients on Medicare (Part B) and Medicaid

*Based on a review of six months of past claim data for major insurance carriers across the US. Last updated 2023.

The GeneSight® Promise

If you decide to use your insurance and we determine that your cost will exceed $330, we will contact you before processing the test and before billing you to make sure you would like to proceed.

Reduced self-pay option

All patients are eligible for the reduced Self-Pay option of $330. Self-Pay may be the most affordable option for patients whose out-of-pocket cost is estimated to be higher than $330, for those whose insurance does not cover the GeneSight test, or for those without insurance.

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2,000,000
people have taken the GeneSight test.

If you think genetic testing could be helpful for you, talk to your doctor about the GeneSight Psychotropic test.

7
clinical studies published in peer-reviewed journals.

GeneSight Psychotropic is the only psychotropic pharmacogenomic test backed by such extensive research.

How does it work?

The GeneSight test is administered by your healthcare provider in their office.

Step 1

Order

The GeneSight test must be ordered by a prescribing clinician who is registered to offer the GeneSight test. This list includes but is not limited to primary care physician, nurse practitioner, physician’s assistant, and/or psychiatrist.

Step 2

Collection

Your doctor collects a DNA sample by painlessly swabbing the inside of your cheek OR you can collect the sample at home using our patient collection kit.

Step 3

Lab

The sample is sent to our lab for analysis.

Step 4

Results

After we receive your sample, your doctor will typically get test results in about 3 days.

Step 5

Consultation

Your doctor can contact our Medical Affairs team for a consultation. Your doctor can then review the results with you on your next visit.

Step 1

Order

The GeneSight test must be ordered by a prescribing clinician who is registered to offer the GeneSight test. This list includes but is not limited to primary care physician, nurse practitioner, physician’s assistant, and/or psychiatrist.

Step 2

Collection

Your doctor collects a DNA sample by painlessly swabbing the inside of your cheek OR you can collect the sample at home using our patient collection kit.

Step 3

Lab

The sample is sent to our lab for analysis.

Step 4

Results

After we receive your sample, your doctor will typically get test results in about 3 days.

Step 5

Consultation

Your doctor can contact our Medical Affairs team for a consultation. Your doctor can then review the results with you on your next visit.

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    Start the Conversation About GeneSight

    The most important step you can take is to talk to your doctor. If you think genetic testing could be helpful for you or someone you care for, download our GeneSight discussion guide.

    A comprehensive report,
personalized for you

    The GeneSight test report may help you avoid multiple medication trials by providing information about which medications may require dose adjustments, be less likely to work, or have an increased risk of side effects based on your genetic information.

    The report also includes information on how a patient’s smoking status may affect their body’s metabolism of certain medications.

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    •  Use as directed
    •  Moderate gene-drug interaction
    •  Significant gene-drug interaction

    The report classifies over 60 mental health medications into three categories.

    The GeneSight test results do not provide information on disease diagnosis, medication allergies, drug-drug interactions, or which medications will work best.

    Your sample is handled with care.

    Generally, samples are destroyed within 60 days of receipt, however, the samples may be destroyed at any time after the testing is completed upon request.

    The process is a simple cheek swab that will be placed in a paper envelope. This drying process ensures the samples remain stable by preventing microbial growth and breakdown of DNA.

    Our lab is located here in the United States, in Mason, OH.

    Hear from others
like you

    "After 25 years of struggling with depression, Bryan found hope again."

    Bryan D., Florida
    Understanding what may not be working made all the difference.
    Charles, Florida

    "Understanding what may not be working made all the difference."

    Read more

    The GeneSight test has meant the world to me
    Jenna D., Indiana

    "The GeneSight test has meant the world to me"

    Read more

    It made my issue manageable for the first time in my entire life
    Rose H., Indiana

    "It made my issue manageable for the first time in my entire life"

    Read more

      Take the next step with the GeneSight test

      Take a step closer to getting the GeneSight test or registering to provide the test to your patients. We will follow up with additional information either via email or phone.

      The GeneSight test must be ordered by a registered clinician. If you are a patient, caregiver or office staff who would like a clinician to be registered to administer the GeneSight test, please include their name and contact information.

      If you are a current registered provider or tested patient, please contact us.

      Take the Next Step - PD

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      Please provide contact and clinic information
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      We are asking for Date of Birth for data verification purposes.










      We are asking for Date of Birth for data verification purposes.

      If you do not have a clinician, we have a directory of healthcare providers who are registered to order the GeneSight test. When you complete this form, we will link you to this directory, so you will have the option to view registered GeneSight providers in your area.







      Your clinician who is currently managing your medication and making treatment decisions can order your GeneSight test.

      If you do not have a clinician, we have a directory of healthcare providers who are registered to order the GeneSight test. When you complete this form, we will link you to this directory, so you will have the option to view registered GeneSight providers in your area.

      Please provide your clinician's information
      The GeneSight test must be ordered by your clinician








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      Already taken the GeneSight test and need access to your results?








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