A faster route to medication insights

What is the GeneSight® Test?

The GeneSight Psychotropic test is designed to analyze clinically important genetic variations that may impact how your patients metabolize and respond to certain mental health medications. These pharmacogenetic insights can provide critical information to inform treatment plans and may help shorten your patients’ road to wellness.

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For each patient, GeneSight provides personalized information about which medications may:

Require dose adjustments

Be less likely to work

Have increased risk of side effects

The GeneSight Advantage

Criteria for making pharmacogenomic calls

GeneSight Psychotropic only includes genes in the algorithm that have a variant that has a significant impact on medication outcomes as demonstrated in multiple well-designed studies. The GeneSight test incorporates information from peer-reviewed literature, the FDA, in-house research, and pharmacogenomics organizations such as CPIC. The analytical validity, or overall accuracy, of the GeneSight Psychotropic test is 99.8%1.

Weighted multi-gene approach

The GeneSight Psychotropic test uses a weighted multi-gene approach that measures multiple genomic variants for each individual and weighs them together to provide comprehensive information about how an individual’s genetic variation may impact their outcomes with certain medications. This method has been shown to be a better predictor of antidepressant blood levels2,3 and clinical outcomes4 compared to single-gene approaches.

$1,000 saved in annual medication costs

According to a large study, on average, patients who received GeneSight testing saved over $1,000 on their total annual medication costs compared to traditional approaches5.

Evidence

There are multiple peer-reviewed publications that support the clinical validity, clinical utility, and economic utility of the GeneSight Psychotropic test. Two largest pharmacogenomic RCTs in mental health PRIME Care (n=1944)6 and GUIDED (n=1167)7 showed significantly improved remission rates for patients with depression who had at least one prior treatment failure.

Backed by extensive research

7 clinical studies published in peer-reviewed journals support the GeneSight test’s effectiveness.

GUIDED clinical study

The largest patient and rater blinded pharmacogenomic study in mental health.1

Key findings

The GeneSight test outperformed treatment as usual.

>11%

relative improvement in depressive symptoms2

>30%

relative improvement in response rates3

>50%

relative improvement in remission rates4

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Get started with easy ordering and complimentary report consults

1

Fill out this form and a GeneSight representative will contact you to complete the registration process so you can begin offering the GeneSight test to your patients.

2

Once registered, place an order on mygenesight.com

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Your practice collects your patient’s DNA sample with a simple cheek swab OR your patient uses the home collection kit.

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The DNA sample is sent to our lab for analysis. After the sample is received, the GeneSight report is typically available in 2 days.

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Use the genetic insights from the GeneSight report to help inform your treatment. Contact our medical team for a complimentary report interpretation consultation.

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Genetic insights to help navigate your patient’s next treatment

The GeneSight Psychotropic report may help you avoid multiple medication trials by providing information about which medications may require dose adjustments, be less likely to work, or have an increased risk of side effects based on your patient’s genetic information.

The report also includes information on how a patient’s smoking status may affect their body’s metabolism of certain medications.

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  •  Use as directed
  •  Moderate gene-drug interaction
  •  Significant gene-drug interaction

The report classifies over 60 mental health medications into three categories.

The GeneSight test results do not provide information on disease diagnosis, medication allergies, drug-drug interactions, or which medications will work best.

Get insights for many types of mental health patients and medication histories

An ideal time to consider the GeneSight test is when treating:

  • New patients with a previous medication failure
  • Patients experiencing lower-than-desired medication response
  • Patients experiencing unwanted side effects
  • Elderly patients
  • Patients with liver damage
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The GeneSight test provides information about your patients that may help reduce medication trial and error.

We’re committed to helping your patients navigate cost

Our goal is to make the GeneSight test affordable and accessible to patients. Insurance can be complicated, and we want you to feel comfortable ordering the test for your patients.

Cost shouldn’t be a barrier to getting critical insights for informing mental health treatment.

98%of patients pay $330 or less for their GeneSight test*

$0is the typical out-of-pocket cost for patients on Medicare (Part B) and Medicaid

And if your patient’s cost is estimated to be more than $330, we’ll contact your patient to discuss their options, including financial assistance and interest-free payment plans for those who qualify.

* Based on a review of six months of past claim data for major insurance carriers across the US. Last updated 2023.

7 clinical studies

Go forward with the GeneSight Test: the only pharmacogenomic test evaluated in 7 clinical studies published in peer-reviewed journals.

Review clinical studies

Clinician resources

FAQs White papers Report interpretation

Hear from other healthcare providers

Tens of thousands of clinicians have ordered the GeneSight test for 3 million patients and counting. Explore what happens when the GeneSight test becomes part of a clinician’s practice through the testimonials shared below.

I found GeneSight helps to build trust with my patients
Johnny Williamson

"I found GeneSight helps to build trust with my patients"

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I don’t want to waste my time guessing. I want to build a good relationship, a trusting relationship with my patient.
Nicole Dano

"I don’t want to waste my time guessing. I want to build a good relationship, a trusting relationship with my patient."

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There is no other test like it
Charlynne Gervais

"There is no other test like it"

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    Hear from other healthcare providers

    The stories shared on this page are individual healthcare providers’ personal experiences with GeneSight. Others may not have the same experience or outcome. Do not make any changes to your current medications or dosing without consulting your healthcare provider.

    Take the next step with the GeneSight test

    Take a step closer to getting the GeneSight test or registering to provide the test to your patients. We will follow up with additional information either via email or phone.

    The GeneSight test must be ordered by a registered clinician. If you are a patient, caregiver or office staff who would like a clinician to be registered to administer the GeneSight test, please include their name and contact information.

    If you are a current registered provider or tested patient, please contact us.

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    If you do not have a clinician, we have a directory of healthcare providers who are registered to order the GeneSight test. When you complete this form, we will link you to this directory, so you will have the option to view registered GeneSight providers in your area.







    Your clinician who is currently managing your medication and making treatment decisions can order your GeneSight test.

    If you do not have a clinician, we have a directory of healthcare providers who are registered to order the GeneSight test. When you complete this form, we will link you to this directory, so you will have the option to view registered GeneSight providers in your area.

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    The GeneSight test must be ordered by your clinician








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    If you are a patient or a caregiver and would like to request a copy of your results, please complete the Patient Report Request form here









    Contact Information

    By submitting your information in this form, you agree that your personal information may be stored and processed in any country where we have facilities or service providers, and by using our “Take the Next Step” page you agree to the possible transfer of information to countries outside of your country of residence, including to the United States, which may provide for different data protection rules than in your country. The information you submit will be utilized for the sole purpose it was submitted for and governed by our Privacy Notice.

    References: 1. Jablonski MR, King N, Wang Y, et al. Analytical validation of a psychiatric pharmacogenomic test. Personalized Medicine. 2018;15(3):189-197. doi:https://doi.org/10.2217/pme-2017-0094. 2. Shelton RC, Parikh SV, Law RA, et al. Combinatorial Pharmacogenomic Algorithm is Predictive of Citalopram and Escitalopram Metabolism in Patients with Major Depressive Disorder. Psychiatry Research. 2020;290:113017. doi:https://doi.org/10.1016/j.psychres.2020.113017. 3. Parikh SV, Law RA, Hain DT, et al. Combinatorial pharmacogenomic algorithm is predictive of sertraline metabolism in patients with major depressive disorder. Psychiatry Research. 2022;308:114354. doi:https://doi.org/10.1016/j.psychres.2021.114354. 4. Rothschild AJ, Parikh SV, Hain D, et al. Clinical validation of combinatorial pharmacogenomic testing and single-gene guidelines in predicting psychotropic medication blood levels and clinical outcomes in patients with depression. Psychiatry Research. 2021;296:113649. doi:https://doi.org/10.1016/j.psychres.2020.113649. 5. Winner JG, Carhart JM, Altar CA, et al. Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation. Current Medical Research and Opinion. 2015;31(9):1633-1643. doi:https://doi.org/10.1185/03007995.2015.1063483. 6. Oslin DW, Lynch KG, Shih MC, et al. Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial. JAMA. 2022;328(2):151-161. doi:https://doi.org/10.1001/jama.2022.9805. 7. Greden JF, Parikh SV, Rothschild AJ, et al. Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study. Journal of Psychiatric Research. 2019;111:59-67. doi:https://doi.org/10.1016/j.jpsychires.2019.01.003.