Finding the right medication for mental health conditions used to be a trial-and-error process. Now, your physician can use the GeneSight® test, which analyzes your DNA to gain a better understanding of what medications are compatible with your genetic makeup.
Your results are presented in an easy-to-read format, with medications categorized into green (use as directed), yellow (moderate gene-drug interaction), and red (significant gene-drug interaction) columns. Using the GeneSight test report, your doctor can personalize your treatment plan, find the right medication faster, and avoid medications that may cause unwanted side effects.
There are four GeneSight tests. Three of the tests (GeneSight Psychotropic, GeneSight ADHD, and GeneSight Analgesic) identify genetically optimal medications to treat certain types of conditions. The fourth test (GeneSight MTHFR) analyzes an important gene to predict your body’s ability to convert folic acid into its active form.
Learning about the four different GeneSight tests will help you understand why your doctor has ordered a specific test.
The GeneSight® Psychotropic Test
What it tests: How your genes affect your response to psychotropic medications
Condition(s): Depression, anxiety, bipolar disorder, posttraumatic stress disorder (PTSD), obsessive compulsive disorder, schizophrenia, and other behavioral health conditions
Benefits: Since there are dozens of medications used to treat mental illnesses, selecting the right one can be a challenging and frustrating process. This test points to which medications are likely to work better or which ones may cause unwanted side effects.
The GeneSight® ADHD Test
What it tests: How your (or your child’s) genes affect your response to stimulant and non-stimulant medications for Attention-Deficit/Hyperactivity Disorder (ADHD)
Benefits: Helps doctors to identify ADHD medications that may be more likely to work as intended and those more likely to cause side effects based on your genetics.
The GeneSight® Analgesic Test
What it tests: How your genes affect your body’s response to FDA-approved opioids, NSAIDs (Nonsteroidal Anti-inflammatory Drugs), and muscle relaxants
Condition(s): Acute or chronic pain, opioid dependency, and osteoarthritis (OA)
Benefits: Assists doctors in helping you feel well again by identifying which pain medications are likely to work better and which ones may cause unwanted side effects based on your genetic make-up.
The GeneSight® MTHFR Test
What it tests: Analyzes an important gene to predict your body’s ability to convert folic acid into its active form of L-methylfolate
Benefits: Folic acid must be in its active form (L-methylfolate) so your body can use it. L- methylfolate is important in the production of neurotransmitters such as dopamine, serotonin, and norepinephrine. This test helps your doctor determine whether you may benefit from folic acid or L-methylfolate supplements.
This document is for educational purposes related to pharmacogenomics and personalized medicine only and should not be considered medical advice. The information is based on scientific opinion from industry experts and is intended to provide additional information to healthcare providers. These materials may be changed, improved, or updated without notice. Assurex Health is not responsible for any errors or omissions contained in third party content. We encourage you to contact us for specific scientific advice regarding our GeneSight® tests. You may print a copy of this document for your own personal noncommercial use. You may not copy any part of this document for any other purpose, and you may not modify any part of this document without the permission of Assurex Health. “GeneSight,” “Assurex” and associated logos are registered trademarks of Assurex Health, Inc. © 2018 Assurex Health, Inc. All rights reserved.