The GeneSight Difference
GeneSight’s Combinatorial Approach
An analysis published in the peer-reviewed Psychiatry Research shows the combinatorial approach used by GeneSight exceeds the effectiveness of single-gene testing at predicting sertraline metabolism in patients with major depressive disorder (MDD). Selective serotonin reuptake inhibitors (SSRIs) are often utilized as the first-line treatment for depression1,2 because they are generally well tolerated; sertraline, in particular, is recognized to have high efficacy and tolerability.3
This is the third study published in Psychiatry Research evaluating the combinatorial approach of the GeneSight test as compared to single-gene testing:
- February 2021 – demonstrating the superior ability of combinatorial pharmacogenomic testing to predict variation in medication blood levels may result in improved patient outcomes
- May 2020 – demonstrating how the combinatorial approach was better at predicting citalopram and escitalopram blood concentrations when compared to single-gene testing
Learn more about the algorithm: https://genesight.com/genetic-insights/understanding-the-genesight-test-algorithm/
1 Gelenberg, A.J., Freeman, M.P., Markowitz, J.C., Rosenbaum, J.F., Thase, M.E., Trivedi, M.H., Van Rhoads, R.S., Reus, V.I., DePaulo Jr, J.R., Fawcett, J.A., 2010. Practice guideline for the treatment of patients with major depressive disorder third edition. Am. J. Psychiatry 167 (10)
2 Kennedy, S.H., Lam, R.W., McIntyre, R.S., Tourjman, S.V., Bhat, V., Blier, P., Hasnain, M., Jollant, F., Levitt, A.J., MacQueen, G.M., 2016. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. Pharmacological treatments. Canadian J. Psychiatry 61 (9), 540–560.
3 Cipriani, A., Furukawa, T.A., Salanti, G., Chaimani, A., Atkinson, L.Z., Ogawa, Y., Leucht, S., Ruhe, H.G., Turner, E.H., Higgins, J.P., 2018. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet North Am. Ed. 391 (10128), 1357–1366. P.