GeneSight MTHFR tests for genetic causes of folate deficiency, which may be more prevalent among depressed patients compared to non-depressed patients. Folate deficiency can result in abnormal homocysteine levels and may interfere with the creation of dopamine, norepinephrine, and serotonin.
The information from the GeneSight test can help you decide if additional folic acid supplementation is necessary based on your patient’s genetic profile. GeneSight provides an objective and personalized approach to treatment.
GeneSight is based on pharmacogenomics—the study of how genes affect a person’s response to medicines. This test was developed in the Assurex Health clinical laboratory and is based on patented technology licensed from two world renowned medical centers, Mayo Clinic and Cincinnati Children’s Hospital Medical Center, who continue to be research collaborators. In clinical use for more than 5 years, GeneSight has over 13,000 registered healthcare providers and over 210,000 patients who have undergone GeneSight testing.
Methylenetetrahydrofolate reductase (MTHFR), which is responsible for the conversion of folic acid and dietary folate to their active form.