Get to know a gene: ANK3
Summary: ANK3 has not been shown to inform on patient medication response and therefore is not a pharmacogenomic marker. As a disease marker, it lacks clinical utility. There is an…
Read MoreGet to know a gene: COMT
Summary: The Val158Met polymorphism (rs4680) in the COMT gene can affect baseline levels of synaptic catecholamines. Several studies have assessed the impact of this polymorphism on treatment outcomes with psychotropic…
Read MoreGet to know a gene: ADRA2A
Summary: The ADRA2A -1291 G>C polymorphism has been studied extensively with methylphenidate treatment outcomes in ADHD. While certain studies have produced inconclusive results, evidence suggests that individuals with the C/C…
Read MoreGet to know a gene: UGT2B15
What is UGT2B15? The UGT2B15 gene encodes an enzyme responsible for glucuronidation, a phase II metabolic reaction that transforms small lipophilic molecules into water-soluble excretable metabolites. The UGT2B15 enzyme is…
Read MoreGet to know a gene: UGT1A4
What is UGT1A4? The UGT1A4 gene encodes an enzyme of the glucuronidation pathway, a phase II metabolism process that transforms small lipophilic molecules into water-soluble excretable metabolites. The UGT1A4 enzyme…
Read MoreGet to know a gene: HTR2A
What is HTR2A? The 5-HT2A receptor, encoded by the HTR2A gene, is responsible for post-synaptic serotonin signaling and is a target for many antipsychotics and antidepressants.1 Two single nucleotide polymorphisms…
Read MoreWhat do I do with an all green report?
A medication falls in the green category when there is no variation found in the patient’s genes that is expected to impact their outcomes with that medication. In other words,…
Read MoreHow do I choose patients for GeneSight® testing?
The choice for psychiatric pharmacogenomic testing is entirely at the discretion of the healthcare provider. While pharmacogenomic testing has the potential to help inform healthcare providers on treatment decisions for…
Read MoreHow is pharmacogenomic testing different from “traditional” molecular diagnostic testing?
The GeneSight® test is a pharmacogenomic test – not a diagnostic test. Diagnostic testing and pharmacogenomic testing are two different types of genetic tests. In some ways they are similar;…
Read MoreWhy doesn’t the GeneSight® test analyze certain genetic variants?
Why does the GeneSight test only test for pharmacogenomic markers and not diagnostic markers? While a great deal of groundbreaking research is being conducted on the genetic etiology of psychiatric…
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